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Immune System

Innate Immunity

Complement System

Introduction- Pathogens and the Immune System

Introduction- The Innate Immune Response

Cells of the Innate Immune Response

Dendritic Cells, Eosinophils, Basophils, Mast Cells and Innate Lymphoid Cells

Phagocytic Cells

Pattern Recognition Receptors (PRRs)

Inflammatory Signaling and Inflammasomes

Acute Inflammation

Chronic Inflammation

Acute inflammatory, Type I interferon and NK cell responses

Acute Phase Response

Strategies to Eliminate Pathogens

Adaptive Immunity

Trafficking and Homing – Lymphocyte Recirculation and Homing

Migration of Central Memory and Effector Memory T-Cells – Lymphocyte Recirculation and Homing

Chemokines – Lymphocyte Recirculation and Homing

Cell Adhesion Molecules (CAMs) – Lymphocyte Recirculation and Homing

Blood_Lymphatic Circulation and High Endothelial Venules – Lymphocyte Recirculation and Homing

Introduction to Lymphocyte Recirculation – Lymphocyte Recirculation and Homing

Secondary Lymphoid Tissues – Lymphocyte Activation

Overview of Lymphoid Tissues – Lymphocyte Activation

Migration and Maturation of Interdigitating Dendritic Cells and T-Cell Differentiation – Lymphocyte Activation

Costimulation – Lymphocyte Activation

T-Dependent, T-Independent Antigens and Class Switching – Humoral Immunity

Antibody Polymers and Antibody Binding to Antigens – Humoral Immunity

Cells of the Adaptive Immune System

Immune Response

Function of Antibodies – Humoral Immunity

Structure of Antibodies and Immunoglobulin Domains – Humoral Immunity

Introduction – Humoral Immunity

Introduction – Cell-Mediated Immunity

Cytokines, Interferons, Interleukins and Colony Stimulating Factors – Cell-Mediated Immunity

Chemokines, Tumor Necrosis Factors and Transforming Growth Factors – Cell-Mediated Immunity

Gamma-Delta T-Cells, T-Cell Receptor and Alpha-Beta T-Cells – Cell-Mediated Immunity

Regulatory T-Cells, Cytotoxic T-Cells, Macrophages and Intraepithelial Lymphocytes – Cell-Mediated Immunity

Th0, Th1 and Th2 Cells – Cell-Mediated Immunity

Functional Modes of Cytokines and Cytokine Receptor Signaling – Cell-Mediated ImmunityFunctional Modes of Cytokines and Cytokine Receptor Signaling – Cell-Mediated Immunity

Therapeutic Blocking of Pathological Cytokines and Therapeutic Cytokines – Cell-Mediated Immunity

B- and T-Cell Activation – Lymphocyte Activation

Germinal Center – Lymphocyte Activation

B-Cell Differentiation – Lymphocyte Activation

Lymphocyte Development

Organization of the Immune System

B-Cell Development in the Bone Marrow – Lymphocyte Development

T-Cell Development – Lymphocyte Development

T-Cell Development in Thymus and Genetic Recombination of TCR – Lymphocyte Development

Immunoglobulin Genes and Recombination – Lymphocyte Development

Class Switch Recombination, Co-Expression and B-Cell Development – Lymphocyte Development

Antibody Variable Region Diversity – Lymphocyte Development

Junctional Diversity, N-Nucleotide Addition and Somatic Hypermutation – Lymphocyte Development

Natural Killer T-Cells (NKT-Cells) – Lymphocyte Development

Recognition of Antigens – Lymphocyte Development

Mediation of Antigen Receptor Genetic Recombination – Lymphocyte Development

Mutations Affecting T-cell Maturation

Antigen Processing & Presentation

Introduction – Antigen Processing and Presentation

Main Pathways and Endogenous_Exogenous Antigens – Antigen Processing and Presentation

Major Histocompatibility Complex (MHC) – Antigen Processing and Presentation

Major Histocompatibility Complex (MHC) and MHC Disparity

Structure of Major Histocompatibility Complex – Antigen Processing and Presentation

Polymorphism and TCR Recognition of Major Histocompatibility Complex – Antigen Processing and Presentation

Diversity of Major Histocompatibility Complex – Antigen Processing and Presentation

Cross-Presentation – Antigen Processing and Presentation

Presentation of Lipid Antigens by CD1 – Antigen Processing and Presentation

Hypersensitivity

Introduction to Hypersensitivity

Hypersensitivity- Types

Hypersensitivity- Type 1 – Causes

Hypersensitivity- Type 2

Hypersensitivity- Type 3

Hypersensitivity- Type 4

Allergy- Genetics and IgE

Allergy- Diagnosis, Therapy and Treatment of Asthma

IgE, Mast Cells and Eosinophils

Autoimmune Hemolytic Anemia

Acute Rheumatic Fever

Introduction to Autoimmune Diseases

Autoimmune Diseases- Types

Autoimmune Diseases- Therapy

Immune Tolerance and Autoimmune Regulator (AIRE)

Genetic Susceptibility to Autoimmune Diseases and Mechanisms

Goodpasture’s Syndrome, Hashimoto’s Thyroiditis, Graves’ Disease and Type I Diabetes

Rheumatoid Arthritis (RA)

Systemic Lupus Erythematosus (SLE)

Multiple Sclerosis (MS) and Guillain-Barré Syndrome (GBS)

Immunodeficiencies

Leukemia, Lymphoma & Myeloma

Introduction – Primary Immunodeficiency

Diagnosis – Primary Immunodeficiency

Treatment – Primary Immunodeficiency

Complement Deficiencies – Primary Immunodeficiency

Phagocytic Cell Disorders – Primary Immunodeficiency

Severe Combined Immunodeficiency (SCID) – Primary Immunodeficiency

T-Cell Immunodeficiencies- Hyper IgM Syndrome, Wiskott-Aldrich Syndrome and MHC Class II Deficiency – Primary Immunodeficiency

Primary Immunodeficiencies Associated with Autoimmune Disease

Autoinflammatory Disorders – Primary Immunodeficiency

Introduction – Secondary Immunodeficiency

Causes- Aging & Infections – Secondary Immunodeficiency Diseases

Causes- Immaturity & Pregnancy – Secondary Immunodeficiency Diseases

HIV Infection and HIV Life Cycle– Secondary Immunodeficiency Diseases

HIV Disease- Clinical Course, Treatment & Prophylaxis – Secondary Immunodeficiency Diseases

History of Vaccination

Types of Vaccines (1)- Live Attenuated Vaccines and Inactivated Vaccines

Vaccination- Subunit Vaccines, Toxoid Vaccines, Conjugate Vaccines

Vaccine Components- Antigen, Carrier and Adjuvant

Future Needs for Vaccines- Influenza, Malaria, Tuberculosis, HIV

Tumor Immunology

Introduction to Tumor Immunology

Immune Response to Tumors- Tumor Antigens and Antitumor Immunity

Tumor Evasion of the Immune Response and Immune Checkpoint Blockade

Tumor-Infiltrating NK Cells

Monoclonal Antibodies and Nonspecific Immunotherapy

Immunodiagnostics

Flow Cytometry and Fluorescence-Activated Cell Sorter (FACS)

Introduction to Immunodiagnostics

Immunoassays- ELISA, RIA and Luminex™

Electrophoresis and Western Blot

Immunodiagnostic Methods- Agglutination, Nephelometry, Immunoprecipitation and Radial Immunodiffusion

Immunofluorescence and Immunohistochemistry

Evaluation of Cellular Activity

Preparation of Antibodies

Transplant Immunology

Introduction to the Problems and Rules of Transplantation

Allograft Rejection and Blood Transfusion

Direct and Indirect Alloantigen Recognition

Tissue Typing, Immunosuppressive Drugs and GVHD

Blood Transfusion

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Allergy- Diagnosis, Therapy and Treatment of Asthma

Immune System
Hypersensitivity
Allergy- Diagnosis, Therapy and Treatment of Asthma

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