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Immune System

محتوای دوره

Innate Immunity
13 موضوع
Complement System
Introduction- Pathogens and the Immune System
Introduction- The Innate Immune Response
Cells of the Innate Immune Response
Dendritic Cells, Eosinophils, Basophils, Mast Cells and Innate Lymphoid Cells
Phagocytic Cells
Pattern Recognition Receptors (PRRs)
Inflammatory Signaling and Inflammasomes
Acute Inflammation
Chronic Inflammation
Acute inflammatory, Type I interferon and NK cell responses
Acute Phase Response
Strategies to Eliminate Pathogens
Adaptive Immunity
28 موضوع
Trafficking and Homing – Lymphocyte Recirculation and Homing
Migration of Central Memory and Effector Memory T-Cells – Lymphocyte Recirculation and Homing
Chemokines – Lymphocyte Recirculation and Homing
Cell Adhesion Molecules (CAMs) – Lymphocyte Recirculation and Homing
Blood_Lymphatic Circulation and High Endothelial Venules – Lymphocyte Recirculation and Homing
Introduction to Lymphocyte Recirculation – Lymphocyte Recirculation and Homing
Secondary Lymphoid Tissues – Lymphocyte Activation
Overview of Lymphoid Tissues – Lymphocyte Activation
Migration and Maturation of Interdigitating Dendritic Cells and T-Cell Differentiation – Lymphocyte Activation
Costimulation – Lymphocyte Activation
T-Dependent, T-Independent Antigens and Class Switching – Humoral Immunity
Antibody Polymers and Antibody Binding to Antigens – Humoral Immunity
Cells of the Adaptive Immune System
Immune Response
Function of Antibodies – Humoral Immunity
Structure of Antibodies and Immunoglobulin Domains – Humoral Immunity
Introduction – Humoral Immunity
Introduction – Cell-Mediated Immunity
Cytokines, Interferons, Interleukins and Colony Stimulating Factors – Cell-Mediated Immunity
Chemokines, Tumor Necrosis Factors and Transforming Growth Factors – Cell-Mediated Immunity
Gamma-Delta T-Cells, T-Cell Receptor and Alpha-Beta T-Cells – Cell-Mediated Immunity
Regulatory T-Cells, Cytotoxic T-Cells, Macrophages and Intraepithelial Lymphocytes – Cell-Mediated Immunity
Th0, Th1 and Th2 Cells – Cell-Mediated Immunity
Functional Modes of Cytokines and Cytokine Receptor Signaling – Cell-Mediated ImmunityFunctional Modes of Cytokines and Cytokine Receptor Signaling – Cell-Mediated Immunity
Therapeutic Blocking of Pathological Cytokines and Therapeutic Cytokines – Cell-Mediated Immunity
B- and T-Cell Activation – Lymphocyte Activation
Germinal Center – Lymphocyte Activation
B-Cell Differentiation – Lymphocyte Activation
Lymphocyte Development
12 موضوع
Organization of the Immune System
B-Cell Development in the Bone Marrow – Lymphocyte Development
T-Cell Development – Lymphocyte Development
T-Cell Development in Thymus and Genetic Recombination of TCR – Lymphocyte Development
Immunoglobulin Genes and Recombination – Lymphocyte Development
Class Switch Recombination, Co-Expression and B-Cell Development – Lymphocyte Development
Antibody Variable Region Diversity – Lymphocyte Development
Junctional Diversity, N-Nucleotide Addition and Somatic Hypermutation – Lymphocyte Development
Natural Killer T-Cells (NKT-Cells) – Lymphocyte Development
Recognition of Antigens – Lymphocyte Development
Mediation of Antigen Receptor Genetic Recombination – Lymphocyte Development
Mutations Affecting T-cell Maturation
Antigen Processing & Presentation
9 موضوع
Introduction – Antigen Processing and Presentation
Main Pathways and Endogenous_Exogenous Antigens – Antigen Processing and Presentation
Major Histocompatibility Complex (MHC) – Antigen Processing and Presentation
Major Histocompatibility Complex (MHC) and MHC Disparity
Structure of Major Histocompatibility Complex – Antigen Processing and Presentation
Polymorphism and TCR Recognition of Major Histocompatibility Complex – Antigen Processing and Presentation
Diversity of Major Histocompatibility Complex – Antigen Processing and Presentation
Cross-Presentation – Antigen Processing and Presentation
Presentation of Lipid Antigens by CD1 – Antigen Processing and Presentation
Hypersensitivity
10 موضوع
Introduction to Hypersensitivity
Hypersensitivity- Types
Hypersensitivity- Type 1 – Causes
Hypersensitivity- Type 2
Hypersensitivity- Type 3
Hypersensitivity- Type 4
Allergy- Genetics and IgE
Allergy- Diagnosis, Therapy and Treatment of Asthma
IgE, Mast Cells and Eosinophils
Autoimmune Hemolytic Anemia
Autoimmunity
11 موضوع
Acute Rheumatic Fever
Introduction to Autoimmune Diseases
Autoimmune Diseases- Types
Autoimmune Diseases- Therapy
Immune Tolerance and Autoimmune Regulator (AIRE)
Genetic Susceptibility to Autoimmune Diseases and Mechanisms
Goodpasture’s Syndrome, Hashimoto’s Thyroiditis, Graves’ Disease and Type I Diabetes
Rheumatoid Arthritis (RA)
Systemic Lupus Erythematosus (SLE)
Multiple Sclerosis (MS) and Guillain-Barré Syndrome (GBS)
Celiac Disease
Immunodeficiencies
15 موضوع
Leukemia, Lymphoma & Myeloma
Introduction – Primary Immunodeficiency
Diagnosis – Primary Immunodeficiency
Treatment – Primary Immunodeficiency
Complement Deficiencies – Primary Immunodeficiency
Phagocytic Cell Disorders – Primary Immunodeficiency
Severe Combined Immunodeficiency (SCID) – Primary Immunodeficiency
T-Cell Immunodeficiencies- Hyper IgM Syndrome, Wiskott-Aldrich Syndrome and MHC Class II Deficiency – Primary Immunodeficiency
Primary Immunodeficiencies Associated with Autoimmune Disease
Autoinflammatory Disorders – Primary Immunodeficiency
Introduction – Secondary Immunodeficiency
Causes- Aging & Infections – Secondary Immunodeficiency Diseases
Causes- Immaturity & Pregnancy – Secondary Immunodeficiency Diseases
HIV Infection and HIV Life Cycle– Secondary Immunodeficiency Diseases
HIV Disease- Clinical Course, Treatment & Prophylaxis – Secondary Immunodeficiency Diseases
Vaccines
5 موضوع
History of Vaccination
Types of Vaccines (1)- Live Attenuated Vaccines and Inactivated Vaccines
Vaccination- Subunit Vaccines, Toxoid Vaccines, Conjugate Vaccines
Vaccine Components- Antigen, Carrier and Adjuvant
Future Needs for Vaccines- Influenza, Malaria, Tuberculosis, HIV
Tumor Immunology
6 موضوع
Introduction to Tumor Immunology
Immune Response to Tumors- Tumor Antigens and Antitumor Immunity
Tumor Evasion of the Immune Response and Immune Checkpoint Blockade
Tumor-Infiltrating NK Cells
Tumor Vaccines
Monoclonal Antibodies and Nonspecific Immunotherapy
Immunodiagnostics
8 موضوع
Flow Cytometry and Fluorescence-Activated Cell Sorter (FACS)
Introduction to Immunodiagnostics
Immunoassays- ELISA, RIA and Luminex™
Electrophoresis and Western Blot
Immunodiagnostic Methods- Agglutination, Nephelometry, Immunoprecipitation and Radial Immunodiffusion
Immunofluorescence and Immunohistochemistry
Evaluation of Cellular Activity
Preparation of Antibodies
Transplant Immunology
5 موضوع
Introduction to the Problems and Rules of Transplantation
Allograft Rejection and Blood Transfusion
Direct and Indirect Alloantigen Recognition
Tissue Typing, Immunosuppressive Drugs and GVHD
Blood Transfusion